Irvine, Calif., Dec. 3, 2024 – A research team co-led by the University of California, Irvine has discovered that accumulated DNA damage in the retina is a key contributor to age-related macular degeneration and that targeting specific retinal cell types may lead to treatments that slow or stop progression.

Affecting approximately 200,000 Americans annually, AMD is a major cause of blindness in people over 50. It exists in two forms: wet, which is treated with well-established therapies, and dry, which lacks effective remedies.

The study, recently published online in the journal Aging Cell, reveals how DNA damage, a hallmark of aging, compromises the retina’s function and accelerates vision loss.

“Our findings highlight the critical role DNA damage repair plays in maintaining retina health for good vision,” said co-corresponding author Dorota Skowronska-Krawczyk, UC Irvine associate professor of physiology and biophysics. “Because age is the strongest risk factor for AMD, gaining deeper insights into the underlying biology of aging in the eye is essential for developing effective therapies.”

The retina, a light-sensitive tissue at the back of the eye, consumes more oxygen than any other tissue in the body and relies on the retinal pigment epithelium cell layer to function properly. Its exposure to light and intense metabolic activity makes it highly vulnerable to oxidative stress and the accumulation of DNA damage over time, a process closely linked to aging. Understanding the delicate relationship between the retina and the retinal pigment epithelium and the basic mechanism driving age-related changes is crucial for developing new approaches to combat AMD.

The team compared a mouse model with reduced levels of ERCC1-XPF, a DNA repair enzyme, with both young, healthy mice and naturally aging mice. By just 3 months of age, the model showed signs of visual impairment, structural alterations in the retina, abnormal blood vessel formation, and shifts in gene expression and metabolism, as well as mitochondrial dysfunction in the retinal pigment epithelium. All these changes mirror those seen in natural human eye aging.

“The more we know about how DNA damage contributes to eye diseases like AMD, [the better] we can develop interventions that address the root causes of vision loss. These could include strategies to counteract oxidative stress, enhance DNA repair or even remove damaged cells before they cause harm,” Skowronska-Krawczyk said. “We plan to investigate which cell types drive age-related changes by selectively impairing DNA mechanisms. Our goal is to advance the development of preventative interventions that significantly reduce the burden of age-related vision loss and improve the quality of life for millions.”

Team members also included William Cho, UC Irvine physiology and biophysics project scientist; co-corresponding author Dr. Laura J. Niedernhofer, professor and director of the University of Minnesota Institute on the Biology of Aging & Metabolism; and faculty and students from the University of Minnesota, the University of Florida and Columbia University. See the full list here.

This work was supported by the University of Minnesota Foundation and a generous donation from Cecilee Faster; and National Institutes of Health grants R01 AG063543, U19AG056278, U54AG079754 and P30 EY034070.

About UC Irvine’s Brilliant Future campaign: Publicly launched on Oct. 4, 2019, the Brilliant Future campaign aims to raise awareness and support for UC Irvine. By engaging 75,000 alumni and garnering $2 billion in philanthropic investment, UC Irvine seeks to reach new heights of excellence in student success, health and wellness, research and more. The School of Medicine plays a vital role in the success of the campaign. Learn more by visiting https://brilliantfuture.uci.edu/uci-school-of-medicine.

About the University of California, Irvine: Founded in 1965, UC Irvine is a member of the prestigious Association of American Universities and is ranked among the nation’s top 10 public universities by U.S. News & World Report. The campus has produced five Nobel laureates and is known for its academic achievement, premier research, innovation and anteater mascot. Led by Chancellor Howard Gillman, UC Irvine has more than 36,000 students and offers 224 degree programs. It’s located in one of the world’s safest and most economically vibrant communities and is Orange County’s second-largest employer, contributing $7 billion annually to the local economy and $8 billion statewide. For more on UC Irvine, visit www.uci.edu.

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